SYNTHESIS OF 4-HYDROXY-1-METHYL-4-(2-FURYL)-3-(2-FURYLHYDROXYMETHYL)PIPERIDINE AND TRANSFORMATION INTO PERHYDRO[1,3,2]DIOXABORININO[5,4-c]PYRIDINE

Having been synthesized successfully heterocyclic system, namely 2-aryl-N-methyl-4,8a-di(2-furyl)perhydro[1,3,2]dioxaborinino-[5,4-c]pyridine contains two piperidine and dioxaborinine rings. This new heterocyclic systemwas prepared from the reaction of 4-hydroxy-1-methyl-4-(2-furyl)-3-(2-furylhydroxymethyl)piperidineand some derivatives of arylboronic acid. The structure of new substances was confirmed by physical-chemical method including 1Н NMR, IR, MS. Futhermore, PASS onlineprogram investigated that di(2-furyl)perhydro[1,3,2]dioxaborinino[5,4-c]pyridine derivatives have high potential of bioactivities such as dermatology, spasmology,anticoagulant andantipsoriatic agent … which promote us to develop the new method affording this kind of compounds.

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Nguồn http://repository.vnu.edu.vn
Tác giả Nguyen Thi Thanh Phuong, Tran Thi Thanh Van, Le Tuan Anh, Truong Hong Hieu, Tran Thach Van, Dao Thi Nhung, KolyadinaN.M., Soldatenkov A.T.
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Last Updated Tháng 8 16, 2018, 10:12 (ICT)
Được tạo ra Tháng 4 12, 2018, 09:06 (ICT)